Gangrenous Cholecystitis

I came across this interesting tweet today:

Father-of-two Edd Langmead, 44, from Oldham dropped six stone on Mounjaro fat jabs he bought privately online, then on March 19 what he thought was just trapped wind pain hit him hard, he tried over-the-counter remedies but within three days the agony left him doubled over on the floor barely able to speak, his terrified partner rang an ambulance as he feared he was leaving his kids without a dad, doctors diagnosed gangrenous cholecystitis – his gallbladder had turned septic with tissue dying and infection spreading fast, he needed emergency surgery to have the organ removed and surgeons told him he was lucky to survive, the dad is now recovering with pipes hanging out of him, unable to walk or lie down properly, feeling like he's in his nineties, Edd is warning others the rapid weight loss triggered the life-threatening complication and to never buy these jabs privately without GP blood tests.

However, as someone replying to this tweet said:

This of course is exactly what happened to me back in 2016 after I lost about 14kg over a few months, dropping from 77kg to 63kg. Here are Gemini's comments:

The Mechanism of Gallbladder Stress

When a person loses weight very quickly—whether through extreme dieting, fasting, or bariatric surgery—the body’s metabolism shifts in ways that directly impact the gallbladder:

• Cholesterol Supersaturation: During rapid weight loss, the liver secretes more cholesterol into the bile. If the ratio of cholesterol to bile salts becomes unbalanced, the bile becomes "supersaturated," leading to the formation of gallstones. 

• Reduced Gallbladder Motility: When caloric intake is severely restricted, the gallbladder does not contract as frequently as it should to empty bile. This stasis allows sludge and stones to build up, increasing the risk of infection. 

• Inflammation and Necrosis: If a stone blocks the cystic duct, the resulting pressure and inflammation can cut off the blood supply. This leads to ischemia (tissue death), which is the defining characteristic of gangrenous cholecystitis.

If only I'd known. Anyway, I'm still alive but minus a gall bladder. Life goes on.